A supplement said to help prevent certain types of cancer
Calcium D-glucarate is a calcium salt made of calcium and glucaric acid, a chemical compound found naturally in the body and in foods like oranges, grapefruit, apples, and broccoli. Calcium D-glucarate is used for preventing certain types of cancer. It is thought to decrease the body's levels of the hormone estrogen, strengthening your defense against hormone-dependent cancers, such as breast and prostate cancers.
In addition, calcium D-glucarate is said to aid in detoxification by eliminating cancer-causing agents, toxins, and steroid hormones from the body.
Preliminary research suggests calcium D-glucarate may help prevent certain cancers. The purported benefits of this supplement come from the D-glucarate component, not the calcium.
However, most of the findings on its health effects come from laboratory research and animal-based studies. Results would need to be replicated in humans to be considered applicable.
Here's a look at where research on this supplement stands.
Prostate, Breast, and Colon Cancers
In a 2002 report published in Alternative Medicine Review investigators analyzed the available research on calcium-D-glucarate and found that it may inhibit beta-glucuronidase—an enzyme associated with increased risk for various hormone-dependent cancers, such as breast, prostate, and colon cancers— when it occurs at elevated levels.
A 2007 study published in Oncology Letters determined that calcium D-glucarate may help fight lung cancer.
In tests on mice, researchers found that calcium D-glucarate helped inhibit the growth of cancerous tumors in the lungs by curbing inflammation and inducing apoptosis (a type of programmed cell death essential for stopping the proliferation of cancer cells).
There's also some evidence that calcium D-glucarate may protect against skin cancer. For example, a 2007 study published in the Journal of Environmental Pathology, Toxicology, and Oncology found that treating mice with calcium D-glucarate helped suppress the development of skin cancer by inducing apoptosis.
Although calcium D-glucarate shows promise as an anti-cancer agent, there is currently a lack of clinical trials testing the use of it in the treatment of any health condition.
Possible Side Effects
There isn't a lot of research into the side effects of calcium D-glucarate, but it is believed to be safe and well-tolerated in humans.
However, due to the lack of research, it should not be taken by women who are pregnant or lactating.
There's some concern that taking calcium D-glucarate in combination with certain medications that are subject to glucuronidation may reduce the medications' effectiveness. Some of these medications include Lipitor (atorvastatin), Ativan (lorazepam), and Tylenol (acetaminophen).
Calcium D-glucarate may also temporarily reduce the levels of other steroid hormones in the body, such as testosterone.